Dr.Mirkin’s eZine

Lifestyle More Important than Genes for Longevity

How long  you live is usually up to you. Extensive research show that most people who live to be 100 have never had any one else in their family also live to be 100.

Longevity researcher James W. Vaupel of the Max Planck Institute in Germany feels that longevity is only three percent genetic and 97 percent environmental.

Compare that to factors that govern how tall you will be, which are more than 80 percent genetic.

For most people, living to 90 or 100  requires a healthful diet, daily exercise and avoidance of exposure to life-shortening infections and toxins.  Centenarians virtually never have diabetes or arteriosclerosis, the most common causes of death in North America today.

One of the best ways to compare the effects of genetics and environment on lifespan is to study twins (Twin Research,December 1998).  The Danish Twin Study showed that a woman whose twin sister lives to be 100 has a four percent chance of living that long (the general population has about a one-percent chance).

The Swedish Twin Registry Study followed 3,656 identical and 6,849
same-sex fraternal twins.  By analyzing the age of death of twins born between 1886 and 1900, the authors found that longevity is determined a maximum of one-third by genetics and more than two-thirds by environmental factors.

Certain genes have been found to shorten or extend life, but reports on these genetic variations show that they are rare and exceptional.  Paul Lichtenstein of the Karolinska Institute reported a gene called APO E4 that shortens life by carrying cholesterol into arteries to form plaques, increasing heart attacks
and dementia.

There is also a long-life gene called CETP-VV that prevents heart attacks and dementia.  People who have CETP-VV have high blood levels of the good HDL cholesterol and large particle size cholesterol that prevent heart attacks. Read the rest of this entry »